基本信息
姓名：李琳琳
职称：副研究员
研究方向：突触水平神经网络三维重建技术
电话：010-82544573
电子邮件：lilinlin@ia.ac.cn
联系地址：北京市海淀区中关村东路95号
教育背景
2009/09-2015/07，北京大学，生命科学学院，生理学，获理学博士学位
2004/09-2009/06，吉林大学，药学院，医学生物工程，获理学学士学位
科研与学术工作经历
2021.05~现在, 中国科学院自动化所，脑图谱与类脑智能实验室，副研究员
2018.09~2021.4, 中国科学院自动化所，类脑智能研究中心，特别助理研究员
2015.07~2018.6, 北京大学，生命科学学院，博士后
论文著作发表情况
1. Expected affine: A registration method for damaged section in serial sections electron microscopy. Tong Xin, Lijun Shen, Linlin Li, Xi Chen, Hua Han. Front Neuroinform.2022 Sep 2;16:944050.
2. Denoising of scanning electron microscope images for biological ultrastructure enhancement. Sheng Chang, Lijun Shen, Linlin Li, Xi Chen , Hua Han. J Bioinform Comput Biol. 2022 Jun;20(3):2250007.
3.Synaptic degeneration in the prefrontal cortex of a rat AD model revealed by volume electron microscopy. Yi Jiang, Linlin Li, Keliang Pang, Jiazheng Liu, Bohao Chen , Jingbin Yuan, Lijun Shen, Xi Chen, Bai Lu, Hua Han. Journal of Molecular Cell Biology. 2022 Mar 3;mjac012. （共同第一作者）
4. An App knock-in rat model for Alzheimer’s disease exhibiting Aβ and tau pathologies, neuronal death and cognitive impairments. Keliang Pang, Richeng Jiang, Wei Zhang, Zhengyi Yang, Lin-Lin Li, Makoto Shimozawa, Simone Tambaro, Johanna Mayer, Baogui Zhang, Man Li, Jiesi Wang, Hang Liu, Ailing Yang, Xi Chen, Jiazheng Liu, Bengt Winblad, Hua Han, Tianzi Jiang, Weiwen Wang, Per Nilsson, Wei Guo, Bai Lu. Cell Research. 2022 Feb;32(2):157-175.
5.A uterus-inspired three dimensional niche drives blastocyst development to the early organogenesis. Zhen Gu, Jia Guo, Jinglei Zhai, Guihai Feng, Xianning Wang, Zili Gao, Kai Li, Shen Ji, Leyun Wang, Yanhong Xu, Xi Chen, Yiming Wang, Shanshan Guo, Man Yang, Linlin Li, Hua Han, Liyuan Jiang, Yongqiang Wen, Liu Wang, Jie Hao, Wei Li Shutao Wang, Hongmei Wang, Qi Gu .Adv Sci(Weinh), 2022 Jul 17;e2202282.
6. A gel-like condensation of Cidec generates lipid-permeable plates for lipid droplet fusion. Developmental cell. Xuchao Lyu, Jia Wang Jianqin Wang, Ye-Sheng Yin, Yun Zhu, Lin-Lin Li, Shuangru Huang, Shuang Peng, Boxin Xue, Rongyu Liao, Shi-Qiang Wang, Mian Long, Thorsten Wohland, Boon Tin Chua, Yujie Sun, Pilong Li, Xiao-Wei Chen, Li Xu, Feng-Jung Chen, Peng Li .2021 Sep 27;56(18):2592-2606.e7.
7. Three-dimensional ATUM-SEM reconstruction and analysis of hepatic endoplasmic reticulum-organelle interactions. Yi Jiang, Linlin Li, Xi Chen Jiazheng Liu, Jingbin Yuan, Qiwei Xie, Hua Han. Journal of Molecular Cell Biology. 2021 Dec 6;13(9):636-645. （共同第一作者）
8. Nanobar array assay revealed complementary roles of BIN1 splice isoforms in cardiac T-tubule morphogenesis. Lin-Lin Li, Qian-Jin Guo, Hsin-Ya Lou, Jing-Hui Liang , Yang Yang, Xin Xing, Hong-Tao Li , Jing Han , Shan Shen , Hui Li, Haihong Ye, Hao Di Wu, Bianxiao Cui, Shi-Qiang Wang. Nano letters. 2020,20(9):6387-6395.(第一作者)
